Dr. B. M. Swamy

Dr. Shashikala Inamdar

Name Dr. Shashikala Inamdar
Position Professor of Biochemistry
Area of specialization Lectins, Glycobiology, Cancer Research, recombinant protein technology for Biopharma and molecular cloning.
Patents 5
Publications 56
MOU signed/created 4
Department P. G. Dept. of Studies in Biochemistry
Institution Karnatak University, Dharwad, India
Postal Address Dr. Shashikala R. Inamdar,Professor of Biochemistry P. G. Dept. of Studies in Biochemistry, Karnatak University Dharwad, Pavate Nagar, Dharwad - 580 003, India.
Email Address srinamdar2009@gmail.com
Mobile +91 9448641393
Year Examination Passed Subject Class obtained University/ Institution
2009-2015 Post doctoral studies Tumour suppressing activity of Sclerotium rolfsii lectin on colon cancer. UKIERI Research Award 2008-2015 Institute of Translational Medicine, University of Liverpool, UK.
2006 Post doctoral studies, as British Common wealth fellow Interaction of TF antigen binding fungal lectins with human colon cancer cell lines British Common wealth Academic Staff Fellowship 2006 Institute of Translational Medicine, University of Liverpool, UK.
1987 Ph. D. Biochemistry Thesis entitled “Studies in Plant Lectins from Euphorbia nivulia Buch. Ham, latex” Karnatak University, Dharwad, India
1980 M. Sc. Biochemistry First Rank with distinction Karnatak University, Dharwad, India
1978 B. Sc. Chemistry, Botany and Zoology First class with distinction Karnatak University, Dharwad, India
Sl.No Position held Department Institution Duration
1 Professor of Biochemistry Dept. of Biochemistry Karnatak University, Dharwad November 2005 to Till date
2 Honorary Visiting Professor School of Translational Medicine University of Liverpool, UK August 2009 to December 2015 (total period 1 year).
3 Honorary Visiting Professor School of Clinical Sciences University of Liverpool, UK October 2006 to March 2007
4 Reader (Associate Professor) Department of Biochemistry Karnatak University, Dharwad November 1997 to November 2005
5 Sr.Lecturer Department of Chemistry Karnatak University, Dharwad November 1993 to November 1997.
6 Lecturer (Assistant Professor) Department of Chemistry Karnatak University, Dharwad November 1988 to November 1993.
7 Scientist B Department of Food Chemistry Central Food Technological
Research Institute, Mysore
February 1987 to March 1988.
8 Lecturer Department of Biochemistry Gulbarga University, Gulbarga August 1983 to June 1985.
Sl.No Position held Department Institution Duration
1 Academic council member Dept. of Biochemistry Karnatak University, Dharwad since 3rd April 2019
2 Chairperson Dept of Studies in Biochemistry Karnatak University, Dharwad 18th Jan 2010 to 18th Jan 2012
3 Chairperson Dept of Studies in Biochemistry Karnatak University, Dharwad 18th Jan 2016 to 20th Jan 2018
4 Chairperson Board of Studies (BOS) in Biochemistry Karnatak University, Dharwad since 2016 till date
5 BOE Chairperson Department of Biochemistry Karnatak University, Dharwad since 2005 till date
6 BOAE chairperson Department of Chemistry Karnatak University, Dharwad 2010 to 2012 and 2016 to2018
7 BOS Member Department of Biochemistry Karnatak University, Dharwad Since 1988.
8 LIC Chairperson Local inspection committee for visiting colleges Gadag District Jan-2019
9 LIC Chairperson Local inspection committee for visiting colleges Hubli-Dharwad District Jan-2018
10 LIC Member Local inspection committee for visiting colleges - Jan-2017
11 LIC Member Local inspection committee for visiting colleges - Jan-2015
12 Science Faculty Member - Karnatak University, Dharwad Since 2005
13 Warden Working Women’s hostel Karnatak University, Dharwad 2002 to 2004
14 Chairperson Women welfare Board Karnatak University, Dharwad 2012 to 2014
15 Coordinator,
Senior supervisor
and Examiner
All the semesters for both CBCS and semester schemes. Karnatak University, Dharwad -
16 KUPGTA member - Karnatak University, Dharwad 1988
17 Member of Committee Preparation of Proposal for UPE, CPEPA, IPLS and DST PURSE Karnatak University, Dharwad 1988
18 Member Planning Monitoring and valuation board Karnatak University, Dharwad since July 2019
19 Member of Committee Evaluation of Annual Report Karnatak University, Dharwad 2018-2019
Sl.No Position held Department Institution Duration
1 Member of BOA Dept. of Biochemistry Central University, Kerala Since 2019
2 Member of BOA Dept. of Biochemistry Mysore University, Mysore Since 2019
3 Member of BOA Dept. of Biochemistry Bangalore University, Bangalore Since 2018
4 Member of BOA Dept. of Biochemistry Mangalore University, Mangalore Since 2018
5 Member of BOA Dept. of Chemistry Central University, Karnataka, Gulbarga Since 2018
6 Member of BOA Dept. of Biochemistry Shivaji University, Kolhapur Since 2018
7 Member of AAA committee Dept. of Biochemistry Kolhapur University Since 2018
8 Member of Recognition of Guideship Dept. of Biochemistry Goa University Since 2019
9 Member VIT Doctoral committee Centre for Bioseparation Technology, VIT, Vellore Since 2015
10 Member of BOS Dept. of Biochemistry Pune University Since 2015
11 Member of BOS Dept. of Biochemistry Goa University Since 2018
12 Member of BOS Dept. of Molecular Biology Bangalore University Since 2017
13 Member of BOE Dept. of Biochemistry Bangalore University, Bangalore Since 2005
14 Member of BOE Dept. of Biochemistry Mysore University, Mysore Since 2005
15 Member of BOE Dept. of Biochemistry Gulbarga University, Gulbarga Since 2005
16 Member of BOE Dept. of Biochemistry Davangere University, Davangere Since 2005
17 Member of BOE Dept. of Biochemistry Shivaji University, Kolhapur Since 2005

Honors & Awards


Navnakshatra Award by TV 9

Awarded as one of the Navnakshatra’s by a national channel TV 9, in the area of Medicine for developing recombinant lectin as anticancer drug and for getting an European patent on 14th Dec. 2019

Silver Medal by FICCI,Texas,USA.

Technology entitled “Recombinant protein with Serological and Cancer diagnostic application” won Silver Medal and was selected for commercialization by India Innovates growth program, organized by FICCI, Lockheed Martin and IC2 Institute, Texas, USA.

British Academic Staff Fellowship

Shashikala Inamdar awarded British Commonwealth Academic Staff Fellowship 2006, to study the interaction of TF antigen binding fungal lectins with human colon cancer cell lines at the University of Liverpool, UK

Agilent Technologies Gift Award

Agilent Technologies USA Research Gift Award of US$ 25,000.00(Twenty five thousand US dollars) awarded by Agilent Technologies Ltd. as a research grant in May 2013

UKIERI Research Award 2008

Recieved UKIERI Research Award by UK India Education and Research initiative in 2008 and the project got extended till 2014. Also got an opportunity to collaborate with University of Liverpool, UK

Honorary position conferred

A position of Honorary Visiting Professor was conferred to Dr. Shashikala Inamdar at the Department of Gastroenterology, Institute of Translational Medicine, University of Liverpool, UK from 2006 to 2007 and from 2009 to 2015

DST Travel Award, UK, 2008

Awarded for attending and presenting a research paper entitled “Pro apoptotic effect on human colon cancer cells of a Thomson Fridenrich antigen binding lectin from Sclerotium rolfsii” at Interlec 23, 23rd International Lectin Conference, held at Universities of Edinburgh and Stiriling, Scotland U.K in July, 2008.

Industry collboration

A project entitled “An integrated approach to develop a process for preparation of recombinants of antitumor Sclerotium rolfsii lectin (SRL) in E. coli" is supported by a grant of Rs. 263 lakhs including company’s contribution,under BIPP, in collaboration with Unichem laboratories Pvt.Ltd. (2014-2016) MoU has been signed.

European Patent granted

European Patent Number 09840273.8-2403/2430041 , 2012 was jointly filed by Unichem Labs Pvt. Ltd. and KUD Commercial rights of all the four patents have been transferred to Unichem Laboratories Pvt.Ltd in 2019 and University received Rs.2.5 crores as compensation.

DST Travel Award, Greece, 2016

DST Travel Award for Attending and presenting work at 21st World Congress on Advances in Oncology to be held at Athens, Greece from 3rd to 6th October 2016.

Fellowships

JRF -UGC Junior Research Fellowship from 01. 04. 1980 to 31. 03. 1982

SRF -UGC Senior Research Fellowship from 01. 04. 1982 to 27. 08. 1983

JRF -CSIR JRF 06. 06. 1985 to 18. 02. 1987 CSIR JRF NET)

Other Achievements

Secured first rank in M. Sc. Ranked firt to the Karnatak University 1980

Acquired National Merit Scholarship 1978-1980

Membership & Fellowship of various National and International professional Bodies

  • Member: CFG (Consortium for Functional Glycomics), USA.
  • Member: International Society for Glycobiology, SFG, USA.
  • Member: International Lectin Society (INTERLEC).
  • Member: Asian Community for Glycoscience and Glycotechnology (ACGG).
  • Member: Indian Association for Cancer research (IACR).
  • Life Member: Society of Biological Chemists (India).
  • Member: Academic council of SDM College of Engineering and Technology Dharwad, 2012 -2014.
  • Member of Governing body, Kittur Rani Chennama Memorial School, Kittur since 2012.

The list of journals for which Dr. Shashikala Indamdar has been an Editor or Peer Reviewer.

  • Cancer Glycobiology of Journal of Glycobiology 2013 OMICS Publishing Group Open Access.
  • International Journal of Biological Macromolecules since 2017.
  • Chemico biological interactions since 2019.
  • Protein & Peptide Letters, Bentham Science Publishers
  • Journal of Gene Medicine.
  • Journal of Proteomics, Proteomics.
  • Journal of Cytology.
  • Fungal Biology, GARJBB.
Receieved Best reviewer certificate by Elsevier, The Netherlands in 2018 for International Journal of Biological Macromolecules since 2017, IF 4.57

Total number of research scholars guided:

No. of research scholars guided : 10
No. of research scholars currently working: 4

Present status of research in Glycobiology:

I have been working on Lectins and cell surface molecules for the past 30 years and working together with my colleague, Dr. B. M. Swamy, retired Professor of Biochemistry, jointly we have established reputed Protein chemistry and lectin laboratory at the Dept. of Biochemistry, Karnatak University.

The major research interest of the group is focused on understanding the structure-function relationship of lectins or carbohydrate binding proteins of fungal and plant origin. Lectins with unique carbohydrate binding specificities are becoming important molecular tools for understanding the structure of cell surface glycans, particularly altered glycosylations during patho-physiological conditions.

The main emphasis is especially on lectins with unique sugar specificity which recognize tumor associated antigens such as TF, Tn, CA 125 and sialyl Lewis antigens as they can be used as diagnostic tools, as targeted drug delivery system. Lectins are also studied for their immunomodulatory effects following their interaction with normal and cancer cells both by in vitro and in vivo studies so as to develop them as possible therapeutic agents.

Identification of signaling pathways following lectin interactions using DNA microarrays and identification of lectin receptors, particularly SRL receptors by proteomics approach have strengthened our research to develop SRL as therapeutic molecule. Detailed in vivo preclinical studies, including biodistribution, toxicity and efficacy have been completed, demonstrating potential of SRL as anticancer agent when injected intra peritoneally. The work is also focused to explore lectins for insecticidal effects using both cutting and chewing as well sucking pests for developing pest resistant transgenic plants.

Papers presented at the International Symposia/ Conferences


1

Title:

N glycan specific lectins from Rhizoctonia bataticola and Cephalosporium curvulum with promising therapeutic and diagnostic potential 0

Presented at: 8th International Translational Cancer Research Conference TCR 2020 held at the Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi, India from February 13-16, 2020

Presented by: Shashikala R. Inamdar

2

Title:

Lectins with unique sugar specificity and their possible clinical applications as cancer diagnostic and therapeutic agents

Presented at: Carcinogenesis 2019; “Emerging Horizons in Oncology: Molecules to Therapeutics Global Perspectives and Challenges” held at Gujarat University, Ahmedabad, India held from 27th to 29th September 2019

Presented by: Shashikala R. Inamdar

3

Title:

Lectins from medicinal plants and fungi; as possible cancer diagnostic and therapeutic agents

Presented at: “Current concepts on the role of Indian medicine and phytoceuticals in maintenance of health” PG Centre, Mangalore University held at Jnana Kaveri, Chikka Aluvara, Kodagu from 16th -17th November, 2018

Presented by: Shashikala R. Inamdar

4

Title:

Tumour suppressing effect of Sclerotium rolfsii lectin and its pharmacokinetics using in vivo models,

Presented at: 21st World Congress on Advances in Oncology and 19th International Symposium on Molecular Medicine held at Athens from 6th to 8th October 2016.

Prepared by: Shashikala R. Inamdar, Anupama S, Preeti Laha, Kamal Pathak, Sanjay Bane, Aravind Ingle, Vikram Gota, Rajiv D. Kalraiya, Jonathan M. Rhodes, Lugang Yu, Bale M. Swamy.

5

Title:

A core fucosylated N-glycan specific mitogenic lectin from cephalosporium curvulum and its role in mediating host parasite interaction leading to mycotic keratitis

Presented at: 7th Asian Community Of Glycoscience and Glycotechnology Conference, ACGG7 held at Matsushima, Miyagi, Japan from 12th -15th November 2015.

Presented by: Shashikala R. Inamdar

6

Title:

Exploiting the carbohydratespecificity of a monocot mannose binding lectin from Remusatia vivipara for developing pest resistant transgenic plants

Presented at:

Prepared by: Shashikala R. Inamdar

7

Title:

Differential expressions of mi RNAs in HT 29 cells by SRL

Presented at: 33rd IACR National Conference, “Discovery, Innovation and Translation in Cancer Research” held at Jaipur University, Jaipur, from 12th to 15th Feb. 2015.

Presented by: Shashikala R. Inamdar

8

Title:

Tuber lectins from Dioscorea bulbifera and Adenia hondala have potential anticancer effects,

Presented at: 6th International Translational Cancer Research Conference (TCR) held at Ahmedabad, India Feb 2016.

Prepared by: Mamta Sharma, Vishwanath H, Sindhur B.R., Bale M. Swamy and Shashikala R. Inamdar

9

Title:

Interaction of N glycans specific Rhizoctonia bataticola lectin (RBL) with human epithelial ovarian cancer cells differentially expressing CA 125

Presented at: Jaipur University, Jaipur, from 12th to 15th Feb. 2015.

Presented by: Prajna Hegde, Mohammed Azharuddin Savanura, Suhas Ballala, Padma Shastryb, Bale M. Swamya Shashikala R. Inamdar

10

Title:

Characterization of anti-tumor Sclerotium rolfsii lectin (SRL) binding membrane proteins from human colon epithelial cancer HT29 cells; a proteomics study

Presented at: International 6th Asian community of glycosciences and glycotechnology School of Life Sciences and School of Chemistry University of Hyderabad, Hyderabad, India. 9th-12th Dec 2014.

Prepared by: Srikanth Barkeer, Ravindra Gudihal, Sachin Eligar, Prajna Hegde, Lu-Gang Yu, Bale M Swamy, Shashikala R Inamdar

11

Title:

Identification of SRL binding receptors on human colon cancer cells using micro-fluidic based LC system with an advanced QTOF MS

Presented at: ASMS, USA, 2014.

Presented by: Ravindra Gudihal, Sachin M. Eligar, Srikanth Barkeer,Jonathan M. Rhodes, Lu-Gang Yu, Bale M. Swamy, Shashikala R. Inamdar

12

Title:

Global gene expression studies and identification of signaling pathways leading to Sclerotium rolfsii lectin (SRL) induced cell death in human colon cancer HT 29 cells.

Presented at: The Annual meeting of Society for Glycobiology, held at St.Petersburg, Florida ,USA from 17th to 20th of Nov.2013.

Presented by: Bale M. Swamy, Srikanth Barkeer, Nilanjan Guha, Ravindra Gudihal, Deepak S A, Vishwanath H, Jonathan M. Rhodes, Lu-Gang Yu, Shashikala R. Inamdar

13

Title:

Identification of pathways leading to HT29 cellular apoptosis following SRL interaction

Presented at: the National Conference on Glycobiology of Cancer Lectins as tools and Cancer 2013 held in Karnatak University Dharwad from 7th to 9th Nov.2013.

Presented by: Srikanth Barkeer1, Arun K S, Nilanjan Guha, Ravindra Gudihal, Deepak S A, Jonathan M, Rhodes, Lu-Gang Yu, Bale M. Swamy, Shashikala R. Inamdar

14

Title:

Core fucosylated N-glycans binding lectin from Cephalosporium curvulum lectin

Presented at: the National Conference on Glycobiology of Cancer Lectins as tools and Cancer 2013 held in Karnatak University Dharwad from 7th to 9th Nov.2013.

Presented by: Sachin M. Eligar, SuhasBallal, Bale M. Swamy, Shashikala R. Inamdar

15

Title:

Sclerotium rolfsii lectin induces strong growth inhibition of human breast cancer cells but less of human normal mammary epithelial cells by induction of cell apoptosis.

Presented at: 332nd Annual Convention of Indian Association for Cancer Research, held at ACBR, New Delhi, Feb 2013.

Presented by: Mohammed Azharuddin Savanur, Sachin M. Eligar, Radha Pujari, Suhas Ballal, Ganapati Bhat, Shyam More, Chen Chen, Aravind Ingle, Pravin Mahajan, Anita Borges, Padma Shastry, Rajiv D. Kalraiya, Bale M. Swamy, Jonathan M. Rhodes, Lu-Gang Yu, Shashikala R. Inamdar

16

Title:

Rhizoctonia bataticola lectin (RBL) induces apoptosis in human ovarian cancer PA-1cells and suppresses tumor growth in vivo.

Presented at: at 32nd Annual Convention of Indian Association for Cancer Research, held at ACBR, New Delhi, Feb 2013.

Presented by: Sachin M. Eligar, Radha Pujari, Mohammed Azharuddin Savanur, Nagaraj N. Nagre, Srikanth Barkeer, Aravind Ingle, Rajiv D. Kalraiya, Bale M. Swamy, Padma Shastry, Shashikala R. Inamdar.

17

Title:

The TF-antigen binding lectin from Sclerotium rolfsii inhibits tumour cell growth by induction of apoptosis.

Presented at: The Annual meeting of Society for Glycobiology held at Seattle USA. Nov. 2011.

Presented by: Shashikala R. Inamdar, Mohammed Azharuddin Savanur, Sachin M. Eligar, Vishwanath B. Chachadi, Nagaraja N. Nagre, Chen Chen, Monica Barclays, Praveen Mahajan, Aravind Ingle, Anita Borges, Padma Shastry, Rajiv D. Kalraiya, Bale M. Swamy, Jonathan M. Rhodes, Lu-Gang Yu.

18

Title:

Apoptotic effect of TF antigen binding lectin from Sclerotium rolfsii on human ovarian cancer cells.

Presented at: Participating Investigators Meeting” held at NIH - Bethesda, Maryland (USA) from July 27 to 29, 2011.

Presented by: Sachin M. Eligar, Radha Pujari, Bale M. Swamy, Padma Shastry, Shashikala R. Inamdar,

19

Title:

Pro apoptotic effect on human colon cancer cells of a Thomson Fridenrich antigen binding lectin from Sclerotium rolfsii

Presented at: Interlec 23, 23rd International Lectin Conference, held at Universities of Edinburgh and Stiriling, Scotland U.K. from July 11-16, 2008.

Presented by: Shashikala R. Inamdar

20

Title:

Cytotoxic effect on human ovarian cells of a lectin from Rhizoctonia bataticola with complex sugar specificity

Presented at: The International symposium on “Novel strategies for targeted prevention and Treatment of cancer” at the School of Life sciences, Jawaharlal Nehru University, New Delhi from December 19-20, 2008.

Presented by: Shashikala R. Inamdar

21

Title:

A mitogenic lectin Rhizoctonia bataticola arrests the growth of human colon epithelial cancer cells

Presented at: International Symposium for “Development of drugs for tomorrow: Challenges and opportunities” held at Adichunchanagiri Institute of Molecular Medical Sciences, Mandya from 1st to 2nd January 2018.

Presented by: Prajna Hegde, Sindhura B.R., Bale M Swamy and Shashikala R Inamdar

22

Title:

Opposite effects of TF binding lectins on human colon epithelial cancer HT29 and SW620 cells is associated with differential expressions of cyclins in G1-S phase

Presented at: International Symposium for “Development of drugs for tomorrow: Challenges and opportunities” held at Adichunchanagiri Institute of Molecular Medical Sciences, Mandya from 1st to 2nd January 2018.

Prepared by: Shivakumar Belur, Srikanth Barkeer, Narasimhappagari Jagadeesh, Bale M Swamy, Lu-Gang Yu, Shashikala R Inamdar

23

Title:

N-glycan specific Rhizoctonia bataticola lectin (RBL) inhibits growth and metastasis of human colorectal cancer

Presented at: 85th Annual meeting of Society of Biological Chemists (India) held at CFTRI, Mysore, 21st to 24th November 2016.

Presented by: Prajna Hegde, Sindhura B.R, Bale M Swamy and Shashikala R Inamdar

24

Title:

N-glycan specific lectin from Remusatia vivipara induces proliferation of PBMC’s but antiproliferative activity in MDA-MB- 468 and HepG2 cancer cells

Presented at: 6th International Translational Cancer Research Conference (TCR) - "Prevention and Treatment of Cancer: Hypes and Hopes." held at Ahmedabad, India Feb 2016.

Presented by: Sindhura B. R, Shashikala. R. Inamdar and Bale M. Swamy

25

Title:

Pharmacokinetic, biodistribution and efficacy studies of the anti tumor lectin from Sclerotium rolfsii (SRL)

Presented at: 6th International Translational Cancer Research Conference (TCR) - "Prevention and Treatment of Cancer: Hypes and Hopes." held at Ahmedabad, India Feb 2016.

Presented by: Anupama S, Preeti Laha, Mamta Sharma, Kamal Pathak, Sanjay Bane, Aravind Ingle, Vikram Gota, Rajiv D. Kalraiya, Bale M. Swamy, Shashikala R. Inamdar

26

Title:

Exploiting the carbohydrate specificity of a monocot mannose binding lectin from Remusatia vivipara for developing pest resistant transgenic plants

Presented at: the 7th Asian Community Of Glycoscience and Glycotechnology Conference, ACGG7 held at Matsushima, Miyagi, Japan from 12th -15th November 2015.

Presented by: Gulam Nabi Vanti, Vishwanathreddy H, IS Katgeri, Shashikala R Inamdar, Bale M. Swamy

27

Title:

Role of a mitogenic lectin, CSL from Cephalosporium curvulum, in mediating host parasite interaction leading to mycotic keratitis

Presented at: at National Symposium ARVO meeting LVPEI, Hyderabad on July 2015.

Presented by: Suhas Ballal, Shivakumar Belur, Sanhita Roy, Rajiv D Kalraiya, B.M. Swamy, Shashikala R Inamdar

28

Title:

A monocot mannose-binding lectin from Remusatia vivipara and its β-prism II Crystal structure

Presented at: 27th International Carbohydrate Symposium (ICS27), Indian Institute of Science, Bangalore, 12th to 17th January 2014.

Presented by: Suguna K, Ganapathi Bhat, Karthika, S.R. Inamdar Bale M Swamy

29

Title:

Identification of SRL binding receptors on human colon cancer cells using microfluidic based LC system with an advanced QTOF-MS,

Presented at: ASMS, Conference on Mass Spectrometry and Allied Topics, USA, 2014.

Presented by: Ravindra Gudihal Sachin M Eligar, Srikanth Barkeer, Jonathan M Rhodes, Lu-Gang Yu, Bale M. Swamy, Shashikala R Inamdar

30

Title:

Cytotoxic effect on human ovarian cancer from Rhizoctonia bataticola

Presented at: at International symposium on novel stratergies for targeted prevention and treatment of cancer held at JNU18th -20 December 2008.

Presented by: Mohammed Azharuddin Savanur, Sachin M. Eligar Bale M. Swamy, Shashikala R Inamdar

31

Title:

Thomsen-Friedenreich antigen binding lectins of phtytopathogenic fungal lectins; Binding studies” International workshop on “Protein folding; Structure and Design

Presented at: International center for theoretical physics (ICTP), Strada costiera, Trieste, Italy from 11th -22nd June, 2001.

Presented by: Bale M. Swamy, Shashikala R Inamdar

32

Title:

A fungal lectin from Sclerotium rolfsii. INTERLEC 14

Presented at: Darjling, India in Nov 1992.

Presented by:Bale M. Swamy, Shashikala R Inamdar

33

Title:

Identification of apoptosis inducing signaling pathways and characterization of SRL binding protein receptors on human colon cancer epithelial cancer HT 29 cells.

Presented at: Experimental Biology 2016 meeting April 2 -6 , San Diego, USA, 2016.

Presented by: Ravindra Gudihal, Sachin M. Eligar, Srikanth Barkeer,Jonathan M. Rhodes, Lu-Gang Yu, Bale M. Swamy, Shashikala R. Inamdar

Total Research Projects:

  • As Principal Investigator : 7
  • As Co-Principal Investigator : 4
  • University Programmes : 3
Sl.No Organisation Name Nature of project Role Project Duration Grant Amount
1 CSIR New Delhi Investigating the role of microbial lectins from pathogenic fungi and bacteria causing mycotic and bacterial keratitis Principal Investigator 2019 to 2022 Rs. 18.5 lakhs
2 DBT sponsored BIPP, Biotechnology Industry Partnership Programme, under BIRAC, with Unichem Laboratories Pvt.Ltd, Mumbai. An integrated approach to develop recombinant Sclerotium rolfsii (SRL) antitumor lectins in E. coli as novel targeted anticancer drug and drug delivery system for human colon and breast cancer, providing affordable health care to cancer patients Principal Investigator 2014-2016 Rs.263 lakhs
3 Agilent Technologies, Pvt. Ltd. Santaclara, USA. Gene and Protein profiling of human colon cancer cells following their interaction with antitumor lectin from Sclerotium rolfsii (SRL) and Identification of lectin binding receptors to explore lectins potential as diagnostic and therapeutic agent. Principal Investigator 2013-2014 Rs.17,22,902
4 CSIR New Delhi Exploring The Potential of RBL, A Cytotoxic Lectin from Rhizoctonia bataticola for Ovarian Cancer Research: Molecular Signalling involved in RBL mediated Cytotoxicity in Ovarian Cancer. Principal Investigator 2012-2015 Rs. 12 lakhs
5 Dept. of Science and Technology, DST India. Investigating the role of a mitogenic lectin from Cephalosporium curvulum, a pathogenic fungus causing mycotic keratitis. Principal Investigator 2012-2015 Rs 47 lakhs
6 UK India Education and Research initiative (UKIERI) British Council. Tumour suppressing activity of Sclerotium rolfsii lectin on colon cancer. Lead Researcher 2008-2014 Rs. 22 lakhs
7 Dept. of Biotechnology, DBT, India Exploring the potential of TF antigen binding property of lectin from Sclerotium rolfsii for its Anti Cancer Effect. India. Principal Investigator 2010 -2013 Rs. 32 lakhs
8 CSIR New Delhi. Evaluation and Mode of action of Sclerotium rolfsii lectin and its recombinant variants for its insecticidal activity. Co-Principal Investigator 2010-2013 Rs. 25 lakhs
9 Dept. of Science and Technology, DST India. TF antigen binding unique lectins from Sclerotium rolfsii and Rhizoctonia bataticola for investigating aberrant Glycosylation and Changes associated with Cancer. Dept. of Science and Technology, India. Co-Principal Investigator 2005 -2008 Rs. 19 lakhs
10 Unichem laboratories, Mumbai Molecular Cloning and Expression of Sclerotium rolfsii Lectin; Exploitation of the Recombinant Protein for Immunological and Serological Applications Co-Principal Investigator 2006 -2009 Rs. 13.25 lakhs
11 CSIR New Delhi Novel Fungal Lectins; Possible Tools for Probing Plant Cell surfaces, as Co-Investigator Co-Principal Investigator 1992-1996 Rs. 8.57 lakhs
12 UGC sponsored University with Potential of Excellence (UPE) with focussed area of research Antitumor activity an integrated approach Deputy Coordinator 2013-2019 Rs. 50crores
13 UGC sponsored CPEPA programme - Member 2013-2017 Rs. 650 lakhs
14 DBT sponsored IPLS programme - Member 2013-2015 1200 lakhs

Total Grant:

  • Individual Grant as Principal Investigator : Rs. 186.7 lakhs
  • Individual Grant as Co-Principal Investigator : Rs. 65.82 lakhs
  • Total Individual grant : Rs. 252.52 lakhs
  • University Programmes Grant : Rs. 6950 lakhs